Explorando o trato gastrointestinal na infecção por SARS-CoV-2
via de infecção, manifestações e impactos na evolução dos pacientes com COVID-19
DOI:
https://doi.org/10.56102/afmo.2023.296Palavras-chave:
SARS-CoV-2, COVID-19, Coronavírus, GastroenteropatiasResumo
Evidências mostraram que a infecção pelo SARS-CoV-2, além de desencadear sintomas respiratórios, pode promover anormalidades e manifestações no trato gastrointestinal (TGI), como dor abdominal, diarreia, náuseas e episódios eméticos. Estudos sugerem uma possível rota de infecção oral-fecal através do TGI após a infecção pelo SARS-CoV-2. Este estudo realizou uma revisão integrativa para identificar a influência da infecção pelo SARS-CoV-2 no TGI. Uma busca automática nas bases de dados PubMed e Scielo foi conduzida e 10 estudos atenderam aos critérios estabelecidos, compreendendo a amostra final. As manifestações do TGI relacionadas ao COVID-19 foram observadas em todos os estudos incluídos nesta revisão. Além disso, outras condições associadas ao TGI, como envolvimento hepático e presença de RNA viral nas fezes, foram relatadas. Estudos adicionais são necessários para elucidar os mecanismos subjacentes à infecção por SARS-CoV-2, manifestações do TGI e agravamento do quadro.
Palavras-chave: SARS-CoV-2, COVID-19, Coronavírus, Gastroenteropatias.
Referências
WHO. World Health Organization. Novel Coronavirus – China. Jan 12, 2020. Disponível em: https://www.who.int/csr/don/12-january-2020-novel-corona-virus- china/en/ 5 mar.2021.
WHO. World Health Organization. Coronavirus disease (COVID-19). 25 mar. 2021. https://www.who.int/emergencies/disease-outbreak-news/item/2020-DON233
Luz Júnior JDCRD, Rosal JHP, Sousa VJDM, Pacífico DKDS, Souza LKMD. Distúrbios gastrointestinais associados à infecção pelo vírus SARS-COV-2: Uma revisão sistemática de literatura. RSD 2021;10:e8910816654. https://doi.org/10.33448/rsd-v10i8.16654.
Lima CMADO. Information about the new coronavirus disease (COVID-19). Radiol Bras 2020;53:V–VI. https://doi.org/10.1590/0100-3984.2020.53.2e1.
Lin L, Jiang X, Zhang Zhenling, Huang S, Zhang Zhenyi, Fang Z, et al. Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection. Gut 2020;69:997–1001. https://doi.org/10.1136/gutjnl-2020-321013.
Tian Y, Rong L, Nian W, He Y. Review article: gastrointestinal features in COVID-19 and the possibility of fecal transmission. Aliment Pharmacol Ther 2020;51:843–51. https://doi.org/10.1111/apt.15731.
Lisboa CS, Lima LDOR, Dayube MN, Oliveira NS, Almeida LMR, Santos PS. Manifestações gastrointestinais em pacientes com Covid-19 / Gastrointestinal manifestations in patients with Covid-19. Braz J Hea Rev 2021;4:10620–38. https://doi.org/10.34119/bjhrv4n3-082.
Pan L, Mu M, Yang P, Sun Y, Wang R, Yan J, et al. Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study. Am J Gastroenterol 2020;115:766–73. https://doi.org/10.14309/ajg.0000000000000620.
Almeida JFMD, Chehter EZ. COVID-19 and the gastrointestinal tract: what do we already know? Einstein (São Paulo) 2020;18:eRW5909. https://doi.org/10.31744/einstein_journal/2020RW5909.
Silva FAFD, Brito BBD, Santos MLC, Marques HS, Silva Júnior RTD, Carvalho LSD, et al. COVID-19 gastrointestinal manifestations: a systematic review. Rev Soc Bras Med Trop 2020;53:e20200714. https://doi.org/10.1590/0037-8682-0714-2020.
Aguila EJT, Cua IHY, Dumagpi JEL, Francisco CPD, Raymundo NTV, Sy-Janairo MLL, et al. COVID-19 and its effects on the digestive system and endoscopy practice. JGH Open 2020;4:324–31. https://doi.org/10.1002/jgh3.12358.
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet 2020;395:507–13. https://doi.org/10.1016/S0140-6736(20)30211-7.
Redd WD, Zhou JC, Hathorn KE, McCarty TR, Bazarbashi AN, Thompson CC, et al. Prevalence and Characteristics of Gastrointestinal Symptoms in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in the United States: A Multicenter Cohort Study. Gastroenterology 2020;159:765-767.e2. https://doi.org/10.1053/j.gastro.2020.04.045.
Zarifian A, Zamiri Bidary M, Arekhi S, Rafiee M, Gholamalizadeh H, Amiriani A, et al. Gastrointestinal and hepatic abnormalities in patients with confirmed COVID-19: A systematic review and meta-analysis. Journal of Medical Virology 2021;93:336–50. https://doi.org/10.1002/jmv.26314.
Natarajan A, Zlitni S, Brooks EF, Vance SE, Dahlen A, Hedlin H, et al. Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA suggest prolonged gastrointestinal infection. Med 2022;3:371-387.e9. https://doi.org/10.1016/j.medj.2022.04.001.
Wang Y, Li Y, Zhang Y, Liu Yun, Liu Yulan. Are gastrointestinal symptoms associated with higher risk of Mortality in COVID-19 patients? A systematic review and meta-analysis. BMC Gastroenterol 2022;22:106. https://doi.org/10.1186/s12876-022-02132-0.
Silva FAFD, Brito BBD, Santos MLC, Marques HS, Júnior RTDS, Carvalho LSD, et al. Transmission of severe acute respiratory syndrome coronavirus 2 via fecal-oral: Current knowledge. WJCC 2021;9:8280–94. https://doi.org/10.12998/wjcc.v9.i28.8280.
Termansen MB, Frische S. Fecal-oral transmission of SARS-CoV-2: A systematic review of evidence from epidemiological and experimental studies. American Journal of Infection Control 2023:S0196655323003565. https://doi.org/10.1016/j.ajic.2023.04.170.
Akbulut G, Yesildemir O. Overview of nutritional approach in hematopoietic stem cell transplantation: COVID-19 update. WJSC 2021;13:1530–48. https://doi.org/10.4252/wjsc.v13.i10.1530.
Ghoshal UC, Ghoshal U, Mathur A, Singh RK, Nath A, Garg A, et al. The Spectrum of Gastrointestinal Symptoms in Patients With Coronavirus Disease-19: Predictors, Relationship With Disease Severity, and Outcome. Clin Transl Gastroenterol 2020;11:e00259. https://doi.org/10.14309/ctg.0000000000000259
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2023 Pedro Lima
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Esta licença permite que outros distribuam, remixem, adaptem e desenvolvam seu trabalho, mesmo comercialmente, desde que creditem a revista pela criação original.