Effects of the description of proton pump inhibitors

Abstract

Introduction: Among the most prescribed drugs worldwide are proton pump inhibitors (PPIs), which are
very useful in the treatment of gastric diseases and are effective because of their low toxicity and blockage of gastric
secretion. Despite its usefulness during treatment, the prolonged use of these drugs can cause serious complications and
losses for the patient who makes continuous use of these drugs. In order to reduce the dose or interrupt the use of drugs that
can cause harm, much has been invested in the description of PPI, which must be carried out in order to consider the
benefits, the purpose of the treatment, the convenience, the age and also patient cooperation. Objective: To carry out a
literature review regarding the negative and positive effects of the description of proton pump inhibitors. Methods:
Narrative review regarding the description of the IBP carried out at the Virtual Health: Library (VHL) and in the SCIELO,
LILACS databases, using the descriptors: description, toxicity, gastric acid and esophagitis. 15 articles published in the
last 12 years were selected, involving the three thematic nuclei: Action of proton pump inhibitors under gastric secretion,
complications due to the prolonged use of PPIs and the importance of the description of PPIs. Results: It is known that
several patients end up self-medicating or continuing previous treatments without medical knowledge; in addition, the use
of many drugs together without prior analysis for the pathology can cause several complications. Thus, the prescription of
these drugs, especially PPIs, is one of the ways to prevent unwanted effects, diseases in the patient and even complications
of pre-existing diseases. The importance of prescribing is to prevent PPIs from being prescribed indefinitely and also to
ensure patient safety by avoiding exposure to the inherent risks of adverse reactions, medication errors, drug interactions
and hospitalizations due to complications for the same. Conclusion: In this sense, although PPIs are potent for gastric
diseases, they are unnecessary for some digestive diseases, hence the importance of a multidisciplinary team to treat the
patient and reduce the prescription of these PPIs. We conclude that, in order to perform the description, it is necessary,
then, to choose the treatment that has a general approach and that brings less harm to the patient's health and life.
Keywords: Description, Toxicity, Gastric acid. Esophagitis.