Comparation of the vascular calcium channel blockade promote by verapamil or nifedipine via docking molecular

Abstract

Cardiovascular diseases are mainly investigated due to risks and prevalence at world. Thereby, research new treatments is a process continuous. Nowadays, the docking molecular analyses are performed to understand relation into structure-function of pharmacology site and its binding protein-ligand, consequently the exactly pharmacological mechanism. The aim of this study was to compare the blockade of calcium voltage-dependent channel promote by verapamil and nifedipine with docking molecular analyses. The experiments were realized with Dockthor and the analyses with Chimera program. The affinity energies were compared by GraphPad Prism program, with t-Test, when values of p < 0.05 were significant. The results showed that the verapamil affinity was better than nifedipine (p < 0.0001). The simulation of configurating for each ligand on channel were different, but both blocking the channel pore, that’s prevent calcium influx in the cell. Those data could be useful to compare the prospection of news drugs be able blocker the calcium channel.