Common genetic aspects between Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder

integrative review

Authors

DOI:

https://doi.org/10.56102/afmo.2023.245

Keywords:

Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Mutations, Genes

Abstract

Objective: The selected studies were analyzed descriptively regarding the common genetic etiology of autism spectrum disorder and attention deficit hyperactivity disorder, allowing for observing, describing, and classifying the data. Methods: We performed a review of the literature on Pubmed and Virtual Health Library (VHL) databases. The search descriptors (Autistic Disorder) OR (Autism Spectrum Disorder) AND (Deficit Disorder) of Attention with Hyperactivity) AND (Genetic Association Studies) OR (Genetics) OR (Heredity) were used in VHL; and ((“Autism Spectrum Disorder” AND “Attention Deficit Disorder with Hyperactivity”) AND (“Genetic Association Studies” OR “Genetics OR Heredity”)) were used in PubMed. Results: A total of 75 studies were identified, 54 in the VHL and 21 in the PubMed. Of these, 18 remained after screening for title and abstract. After full text reading, nine studies were included in this review. Discussion: De novo genic mutations contribute to autism spectrum disorder, and some studies support they might also be determinant for attention deficit hyperactivity disorder. The RFX3, RFX4, and RFX7 genes found in cells of the cerebral cortex of fetuses and adults contribute to linking important regions related to cognition and social behavior. Conclusion: The included studies indicate a correlation between genetic etiologies of autism spectrum disorder and attention deficit hyperactivity disorder.

Author Biographies

Matheus Mastrianni Lima Medeiros, Faculdade de Medicina de Olinda

Student at the Faculdade de Medicina de Olinda. Olinda, Pernambuco, Brazil.

Jade, Faculdade Pernambucana de Saúde

Student at the Faculdade Pernambucana de Saúde. Recife, Pernambuco, Brazil.

João Marcos da Silva Dantas, Faculdade de Medicina de Olinda

Student at the Faculdade de Medicina de Olinda. Olinda, Pernambuco, Brazil.

Helder Elísio Evangelista Vieira, Faculdade de Medicina de Olinda

Doutor em Ciências Biológicas pela Universidade Federal de Pernambuco (2013), Mestre em Biologia de Fungos pela Universidade Federal de Pernambuco (2009), Especialista em Micologia pela Universidade Federal de Pernambuco e Graduado em Licenciatura Plena em Ciências Biológicas pela Universidade Católica de Pernambuco (2005). Até 2020 foi membro do NDE (Núcleo Docente Estruturante) do Curso de Farmácia das Faculdades Integradas de Patos-PB. Nesta mesma Universidade atuou como Professor Titular de Medicina onde lecionou as disciplinas de Citologia e Genética, no Eixo Básico-Clínico I. Também foi docente nas disciplinas de Histologia Geral, Biologia Celular & Molecular, Citogenética e Micologia Clínica nos cursos de Bacharelado em Biomedicina, Farmácia, Enfermagem, Odontologia, Fisioterapia e Nutrição. É professor efetivo da Rede Pública Estadual nas disciplinas de Ciências e Biologia. Tem experiência nas áreas de Micologia e Microbiologia, com ênfase em Genética e Biologia Molecular. Atualmente é discente do Curso de Ciências Médicas da Faculdade de Medicina de Olinda. Olinda, Pernambuco, Brasil.

Albert Eduardo Silva Martins, Faculdade de Medicina de Olinda

Possui graduação em Biomedicina pela Universidade Federal de Pernambuco (1999), mestrado em Genética e Biologia molecular pela Universidade Federal de Pernambuco (2005) e doutorado em Medicina Tropical pela Universidade Federal de Pernambuco (2013). Atualmente é professor-doutor da Faculdade de Medicina de Olinda. Tem experiência na área de genética, biologia molecular, imunologia e hematologia laboratorial, atuando principalmente nos seguintes temas: hematologia laboratorial, imunologia, HPV, imunogenética, educação médica, metodologias ativas, prevalência e epidemiologia. Olinda, Pernambuco, Brasil.

References

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Published

2023-06-29

How to Cite

Medeiros, M. M. L., Martins, J. S., Dantas, J. M. da S., Vieira, H. E. E., & Martins, A. E. S. (2023). Common genetic aspects between Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder: integrative review. Annals of Olinda Medical School, 1(9), 31–42. https://doi.org/10.56102/afmo.2023.245

Issue

Vol. 1 No. 9 (2023)

Section

Artigos de revisão integrativa, sistemática e metanálise

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Copyright (c) 2023 Matheus Mastrianni Lima Medeiros, Jade Souza Martins, João Marcos da Silva Dantas, Helder Elísio Evangelista Vieira, Albert Eduardo Silva Martins

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