Therapeutic applications of Hypericum perforatum (St. John’s wort) for treating anxiety and depression
integrative review
DOI:
https://doi.org/10.56102/afmo.2023.252Keywords:
Anxiety, Depression, Phytopharmaceuticals, Hypericum perforatumAbstract
Hypericum perforatum, known as St. John’s wort, is a popular medicinal plant recom mended in traditional Chinese medicine and prescribed for depression in European coun tries. However, conflicting data were observed regarding its benefits and risks. This study aimed to evaluate phytopharmaceuticals containing Hypericum perforatum extracts for anxiety and depression treatment. An integrative review was performed by searching Literatura Latino-Americana e do Caribe em Saúde (LILACS), Scientific Electronic Library Online (SciELO), and Publisher Medline (PubMed) databases and included studies in Portuguese, English, and Spanish from 2017 to 2022. Randomized clinical trials confirmed the efficacy of the Hypericum perforatum extracts compared with placebo on mild and moderately severe depression. Further randomized controlled studies demonstrated similar efficacy to conventional antidepressants for anxiety and mild to moderate depression. The study concludes the need for more studies to evaluate the efficacy of Hypericum perforatum extracts, especially concerning adverse effects, risks, and drug interactions.
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Copyright (c) 2023 Alany Lima Soares Chagas, Heloise Gabriella Queiroz Moura, Klyvia Renaly Brayner de Sá, Laila Caroline Duarte Nascimento, Larissa Cândida Pereira Guedes, Priscyla Gonçalves Pinheiro Moura, Tharcia Kiara da Cruz
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