Antiulcer effect of Bidens pilosa L. and toxicological safety in rodents: comparative study between stem and root extracts

Authors

  • Abel José Alves Nascimento
  • Bruno Lucena de Lima
  • Artur Danilo Novaes da Silva
  • Helder Carvalho Souza Lima Silva
  • Ricardo Prado Lyra
  • Gabriela Saraiva Dantas
  • Daniela de Alencar Menezes
  • Fabiana Lima Silva
  • Schirley Cristina Almeida Pereira
  • Joelmir Lucena Veiga da Silva

DOI:

https://doi.org/10.56102/afmo.2018.26

Keywords:

Medicinal plant, Plant extract, Anti-ulcer, Toxicity

Abstract

Purpose: To investigate and to compare the extracts of the stalks (Bpc-EtOH) and roots (Bpr-EtOH) from Bidens pilosa on ethanol-gastric ulcer model rats and acude toxicologial screening in mice. Methods: in the ulcer model were accessed the extracts on etanol-induced rat gastric lesions (n = 4-5). To analyze the safety toxicological those extracts in vivo, the acute toxicity screening was perfomed with sigle dose extracts and during three days in mice (n=5). Results: the Bpc-EtOH (150 and 500 mg/kg) protected the rat gastric mucosa layer (ULA=138.0 ± 30.5 and 96.3 ± 11.8 mm2, respectivelly). The Bpr-EtOH induced similar effects on all doses (ULA=178.3 ± 10.0; 67.4 ± 9.5 and 35.5 ± 14.3 mm2) and the most efficacy (Emax) than Bpc-EtOH. The omeprazole (ULA=145.7 ± 19.9 mm2) showed also protective effects as expected. The histophatology analyzes corroborated those results. The maximum dose 500 mg/kg (o.r.) of the
extracts is safe and do not cause damages to animails because dose 2 g/kg (o.r.) in toxicological screening did fail.
Conclusion: The stalks and roots from B. pilosa also present actives metabolites for antiulcer activity, it may be more
concentration in roots or are different than stalks, and both are safe in doses tested.

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Published

2018-08-04

How to Cite

Alves Nascimento, A. J., Lucena de Lima, B., Novaes da Silva, A. D., Carvalho Souza Lima Silva, H., Prado Lyra, R., Saraiva Dantas, G., de Alencar Menezes, D., Lima Silva, F., Almeida Pereira, S. C., & Veiga da Silva, J. L. (2018). Antiulcer effect of Bidens pilosa L. and toxicological safety in rodents: comparative study between stem and root extracts. Annals of Olinda Medical School, 1(2), 10–15. https://doi.org/10.56102/afmo.2018.26

Issue

Vol. 1 No. 2 (2018)

Section

Original Articles

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