Pitavastatin as the preferred statin for control of dyslipidemia in patients with HIV infection using antiretrovirals

Authors

DOI:

https://doi.org/10.56102/afmo.2023.279

Keywords:

Antiretrovirals, HIV, Hyperlipidemia, Hypolipidemic, Statins

Abstract

Objective: explain why pitavastatin is the lipid-lowering agent of choice for lipid control and cardiovascular risk reduction in people infected with HIV. Methods: Searches were carried out in
PubMed and the Virtual Health Library (VHL), using these descriptors, in English and Portuguese: “Pitavastatin”, “HIV”, “Statins”, “Infected by HIV”, “Dyslipidemia” and “Antiretrovirals”. 46 articles were retrieved, reduced, after refinement, to 9, 6 from PubMed and 3 from VHL. Results: The use of antiretrovirals (ARVs) significantly increases lipid alterations in HIV-infected people and should be associated with lipid-lowering therapy with statins. However, as most of them are metabolized by the cytochrome P450 3A4 system, which is inhibited by some ARVs, pitavastatin stands out, since its metabolization process occurs primarily by glucuronidation. Furthermore, it was proved
that this statin showed more inflammatory markers and LDL-c levels than pravastatin, which is metabolized through the same mechanism. Conclusion: Therefore, pitavastatin is preferably the lipid-lowering agent to correct dyslipidemia in HIV-infected patients, due to its minimal drug reactions and greater reduction in lipids and inflammatory markers.

Author Biographies

Thiago José Monteiro Borges da Silva Valente, Faculdade de Medicina de Olinda

Linked to the Faculdade de Medicina de Olinda. Olinda, Pernambuco, Brazil.

Fernando Augusto Pacífico, Faculdade de Medicina de Olinda

Linked to the Faculdade de Medicina de Olinda. Olinda, Pernambuco, Brazil.

Antônio Diego Campos Falcão, Olinda Medical School

Linked to the Olinda Medical School. Olinda, Pernambuco, Brazil.

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Published

2023-12-22

How to Cite

Monteiro Borges da Silva Valente, T. J., Pacífico, F. A., & Campos Falcão, A. D. (2023). Pitavastatin as the preferred statin for control of dyslipidemia in patients with HIV infection using antiretrovirals. Annals of Olinda Medical School, 1(10), 83–95. https://doi.org/10.56102/afmo.2023.279

Issue

Section

Artigos de revisão integrativa, sistemática e metanálise